Control of alternative pre-mRNA splicing by Ca(++) signals.
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ABSTRACT:
SUBMITTER: Xie J
PROVIDER: S-EPMC3500379 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
Control of alternative pre-mRNA splicing by Ca(++) signals.
Biochimica et biophysica acta 20080117 8
Alternative pre-mRNA splicing is a common way of gene expression regulation in metazoans. The selective use of specific exons can be modulated in response to various manipulations that alter Ca(++) signals, particularly in neurons. A number of splicing factors have also been found to be controlled by Ca(++) signals. Moreover, pre-mRNA elements have been identified that are essential and sufficient to mediate Ca(++)-regulated splicing, providing model systems for dissecting the involved molecular ...[more]
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