A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis.
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ABSTRACT:
SUBMITTER: Reilly MC
PROVIDER: S-EPMC3143648 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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A xylosylphosphotransferase of Cryptococcus neoformans acts in protein O-glycan synthesis.
Reilly Morgann C MC Aoki Kazuhiro K Wang Zhuo A ZA Skowyra Michael L ML Williams Matthew M Tiemeyer Michael M Doering Tamara L TL
The Journal of biological chemistry 20110523 30
Cryptococcal meningoencephalitis is an AIDS-defining illness caused by the opportunistic pathogen Cryptococcus neoformans. This organism possesses an elaborate polysaccharide capsule that is unique among pathogenic fungi, and the glycobiology of C. neoformans has been a focus of research in the field. The capsule and other cellular glycans and glycoconjugates have been described, but the machinery responsible for their synthesis remains largely unexplored. We recently discovered Xpt1p, an enzyme ...[more]
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