Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans.
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ABSTRACT:
SUBMITTER: Lee JW
PROVIDER: S-EPMC3147412 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
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Multiple roles of Ypd1 phosphotransfer protein in viability, stress response, and virulence factor regulation in Cryptococcus neoformans.
Lee Jang-Won JW Ko Young-Joon YJ Kim Seo-Young SY Bahn Yong-Sun YS
Eukaryotic cell 20110603 7
Ypd1 is a key phosphorelay protein that controls eukaryotic two-component systems, but its function in Cryptococcus neoformans is not known. Here, we report that Ypd1 is required for the viability of C. neoformans via the Hog1 mitogen-activated protein kinase (MAPK) pathway but plays multiple cellular roles in both a Hog1-dependent and -independent manner. ...[more]
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