Ontology highlight
ABSTRACT:
SUBMITTER: Qiang L
PROVIDER: S-EPMC3151530 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Qiang Liang L Fujita Ryousuke R Yamashita Toru T Angulo Sergio S Rhinn Herve H Rhee David D Doege Claudia C Chau Lily L Aubry Laetitia L Vanti William B WB Moreno Herman H Abeliovich Asa A
Cell 20110801 3
Directed conversion of mature human cells, as from fibroblasts to neurons, is of potential clinical utility for neurological disease modeling as well as cell therapeutics. Here, we describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsic support factors. hiN cells from unaffected individuals display morphological, electrophysiological, and ...[more]