Ontology highlight
ABSTRACT:
SUBMITTER: Blanchard JW
PROVIDER: S-EPMC4466122 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Blanchard Joel W JW Eade Kevin T KT Szűcs Attila A Lo Sardo Valentina V Tsunemoto Rachel K RK Williams Daniel D Sanna Pietro Paolo PP Baldwin Kristin K KK
Nature neuroscience 20141124 1
Humans and mice detect pain, itch, temperature, pressure, stretch and limb position via signaling from peripheral sensory neurons. These neurons are divided into three functional classes (nociceptors/pruritoceptors, mechanoreceptors and proprioceptors) that are distinguished by their selective expression of TrkA, TrkB or TrkC receptors, respectively. We found that transiently coexpressing Brn3a with either Ngn1 or Ngn2 selectively reprogrammed human and mouse fibroblasts to acquire key propertie ...[more]