Ontology highlight
ABSTRACT:
SUBMITTER: Chou RC
PROVIDER: S-EPMC3155777 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chou Richard C RC Kim Nancy D ND Sadik Christian D CD Seung Edward E Lan Yinan Y Byrne Michael H MH Haribabu Bodduluri B Iwakura Yoichiro Y Luster Andrew D AD
Immunity 20100801 2
A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitment into the joint in autoantibody-induced arthritis. We now demonstrate that BLT1 is required for neutrophils to deliver IL-1 into the joint to initiate arthritis. IL-1-expressing n ...[more]