Ontology highlight
ABSTRACT:
SUBMITTER: Disteldorf EM
PROVIDER: S-EPMC4279732 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Journal of the American Society of Nephrology : JASN 20140605 1
Neutrophil trafficking to sites of inflammation is essential for the defense against bacterial and fungal infections, but also contributes to tissue damage in TH17-mediated autoimmunity. This process is regulated by chemokines, which often show an overlapping expression pattern and function in pathogen- and autoimmune-induced inflammatory reactions. Using a murine model of crescentic GN, we show that the pathogenic TH17/IL-17 immune response induces chemokine (C-X-C motif) ligand 5 (CXCL5) expre ...[more]