Ontology highlight
ABSTRACT:
SUBMITTER: Yuan S
PROVIDER: S-EPMC3155825 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20110801 8
Activation of procaspase-9 on the apoptosome is a pivotal step in the intrinsic cell death pathway. We now provide further evidence that caspase recruitment domains of pc-9 and Apaf-1 form a CARD-CARD disk that is flexibly tethered to the apoptosome. In addition, a 3D reconstruction of the pc-9 apoptosome was calculated without symmetry restraints. In this structure, p20 and p10 catalytic domains of a single pc-9 interact with nucleotide binding domains of adjacent Apaf-1 subunits. Together, dis ...[more]