Ontology highlight
ABSTRACT:
SUBMITTER: Rosier BJHM
PROVIDER: S-EPMC7080557 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Rosier Bas J H M BJHM Markvoort Albert J AJ Gumí Audenis Berta B Roodhuizen Job A L JAL den Hamer Anniek A Brunsveld Luc L de Greef Tom F A TFA
Nature catalysis 20200106 3
Living cells regulate key cellular processes by spatial organisation of catalytically active proteins in higher-order signalling complexes. These act as organising centres to facilitate proximity-induced activation and inhibition of multiple intrinsically weakly associating signalling components, which makes elucidation of the underlying protein-protein interactions challenging. Here we show that DNA origami nanostructures provide a programmable molecular platform for the systematic analysis of ...[more]