Ontology highlight
ABSTRACT:
SUBMITTER: Verstrepen BE
PROVIDER: S-EPMC3156919 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Verstrepen Babs E BE Depla Erik E Rollier Christine S CS Mares Gwenny G Drexhage Joost A R JA Priem Sofie S Verschoor Ernst J EJ Koopman Gerrit G Granier Christelle C Dreux Marlène M Cosset François L FL Maertens Geert G Heeney Jonathan L JL
The Journal of infectious diseases 20110901 6
Accumulating evidence indicates that neutralizing antibodies play an important role in protection from chronic hepatitis C virus (HCV) infection. Efforts to elicit such responses by immunization with intact heterodimeric E1E2 envelope proteins have met with limited success. To determine whether antigenic sites, which are not exposed by the combined E1E2 heterodimer structure, are capable of eliciting neutralizing antibody responses, we expressed and purified each as separate recombinant proteins ...[more]