Ontology highlight
ABSTRACT:
SUBMITTER: Kinchen VJ
PROVIDER: S-EPMC6819096 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Kinchen Valerie J VJ Massaccesi Guido G Flyak Andrew I AI Mankowski Madeleine C MC Colbert Michelle D MD Osburn William O WO Ray Stuart C SC Cox Andrea L AL Crowe James E JE Bailey Justin R JR
The Journal of clinical investigation 20190813 11
A vaccine for hepatitis C virus (HCV) is urgently needed. Development of broadly-neutralizing plasma antibodies during acute infection is associated with HCV clearance, but the viral epitopes of these plasma antibodies are unknown. Identification of these epitopes could define the specificity and function of neutralizing antibodies (NAbs) that should be induced by a vaccine. Here, we present development and application of a high-throughput method that deconvolutes polyclonal anti-HCV NAbs in pla ...[more]