Ontology highlight
ABSTRACT:
SUBMITTER: Buranapraditkun S
PROVIDER: S-EPMC3161737 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Buranapraditkun Supranee S Hempel Ursula U Pitakpolrat Patrawadee P Allgaier Rachel L RL Thantivorasit Pattarawat P Lorenzen Sven-Iver SI Sirivichayakul Sunee S Hildebrand William H WH Altfeld Marcus M Brander Christian C Walker Bruce D BD Phanuphak Praphan P Hansasuta Pokrath P Rowland-Jones Sarah L SL Allen Todd M TM Ruxrungtham Kiat K
PloS one 20110822 8
<h4>Background</h4>CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast ...[more]