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Total synthesis of herboxidiene/GEX 1A.

ABSTRACT: A convergent enantioselective synthesis of herboxidiene/GEX 1A (1) is described that features a double stereodifferentiating crotylation, [4 + 2] annulation, and a silicon-based sp2-sp2 cross-coupling to assemble the conjugated diene.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC3164305 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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Total synthesis of herboxidiene/GEX 1A.

Zhang Yun Y Panek James S JS

Organic letters 20070713 16

A convergent enantioselective synthesis of herboxidiene/GEX 1A (1) is described that features a double stereodifferentiating crotylation, [4 + 2] annulation, and a silicon-based sp2-sp2 cross-coupling to assemble the conjugated diene. ...[more]

PMID: 17629295

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