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Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium.

ABSTRACT: To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4-15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 ?M, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC?? and CC?? values of and 143.1 and 976.4 ?M, respectively.

SUBMITTER: Wang Y

PROVIDER: S-EPMC3164379 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium.

Wang Yi Y Zheng Jinkai J Liu Peipei P Wang Wei W Zhu Weiming W

Marine drugs 20110812 8

To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4-15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produc ...[more]

PMID: 21892351

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