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New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2.

ABSTRACT: Three new tripeptide derivatives asterripeptides A-C (1-3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey's method. The isolated compounds 1-3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell lines and inhibition ability of sortase A from Staphylococcus aureus of asterripeptides A-C were investigated.

SUBMITTER: Girich EV

PROVIDER: S-EPMC8780021 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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New Tripeptide Derivatives Asperripeptides A-C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2.

Girich Elena V EV Rasin Anton B AB Popov Roman S RS Yurchenko Ekaterina A EA Chingizova Ekaterina A EA Trinh Phan Thi Hoai PTH Ngoc Ngo Thi Duy NTD Pivkin Mikhail V MV Zhuravleva Olesya I OI Yurchenko Anton N AN

Marine drugs 20220117 1

Three new tripeptide derivatives asterripeptides A-C (1-3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey's method. The isolated compounds 1-3 contain a rare fungi cinnamic acid residue. The cytotoxicity of isolated compounds against several cancer cell ...[more]

PMID: 35049932

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