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Transmission clustering drives the onward spread of the HIV epidemic among men who have sex with men in Quebec.


ABSTRACT: Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n = 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (?(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.

SUBMITTER: Brenner BG 

PROVIDER: S-EPMC3164430 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Transmission clustering drives the onward spread of the HIV epidemic among men who have sex with men in Quebec.

Brenner Bluma G BG   Roger Michel M   Stephens David D   Moisi Daniela D   Hardy Isabelle I   Weinberg Jonathan J   Turgel Reuven R   Charest Hugues H   Koopman James J   Wainberg Mark A MA  

The Journal of infectious diseases 20111001 7


Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n = 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (χ(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-2  ...[more]

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