Harmonin inhibits presynaptic Cav1.3 Ca²? channels in mouse inner hair cells.
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ABSTRACT:
SUBMITTER: Gregory FD
PROVIDER: S-EPMC3164920 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.
Gregory Frederick D FD Bryan Keith E KE Pangršič Tina T Calin-Jageman Irina E IE Moser Tobias T Lee Amy A
Nature neuroscience 20110807 9
Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway. ...[more]
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