Ontology highlight
ABSTRACT:
SUBMITTER: Dzirasa K
PROVIDER: S-EPMC3165036 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Dzirasa Kafui K Coque Laurent L Sidor Michelle M MM Kumar Sunil S Dancy Elizabeth A EA Takahashi Joseph S JS McClung Colleen A CA Nicolelis Miguel A L MA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20101201 48
Polymorphisms in circadian genes such as CLOCK convey risk for bipolar disorder. While studies have begun to elucidate the molecular mechanism whereby disruption of Clock alters cellular function within mesolimbic brain regions, little remains known about how these changes alter gross neural circuit function and generate mania-like behaviors in Clock-Δ19 mice. Here we show that the phasic entrainment of nucleus accumbens (NAC) low-gamma (30-55 Hz) oscillations to delta (1-4 Hz) oscillations is n ...[more]