Ontology highlight
ABSTRACT:
SUBMITTER: Lin CD
PROVIDER: S-EPMC3165462 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Lin Chia-Der CD Lai Cheng-Kuo CK Lin Yu-Hsin YH Hsieh Jer-Tsong JT Sing Yu-Ting YT Chang Yun-Chieh YC Chen Kai-Chuan KC Wang Wen-Ching WC Su Hong-Lin HL Lai Chih-Ho CH
Infection and immunity 20110705 9
Campylobacter jejuni is a common cause of pediatric diarrhea worldwide. Cytolethal distending toxin, produced by Campylobacter jejuni, is a putative virulence factor that induces cell cycle arrest and apoptosis in eukaryotic cells. Cellular cholesterol, a major component of lipid rafts, has a pivotal role in regulating signaling transduction and protein trafficking as well as pathogen internalization. In this study, we demonstrated that cell intoxication by Campylobacter jejuni cytolethal disten ...[more]