Ontology highlight
ABSTRACT:
SUBMITTER: Bokesch HR
PROVIDER: S-EPMC3166232 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Bokesch Heidi Rose HR Gardella Roberta Scott RS Rabe Daniel Christopher DC Bottaro Donald Paul DP Linehan William Marston WM McMahon James Brislin JB McKee Tawnya Carlene TC
Chemical & pharmaceutical bulletin 20110101 9
A new trimethoxycinnamoyl-2-pyrrolinone alkaloid, langkamide (1), along with the known compounds piplartine (2) and 3,4,5-trimethoxycinnamic acid (3) were isolated from the roots and stems of the shrub Piper sarmentosum ROXB. The structures were established by spectroscopic analyses and comparison of their spectral data with values reported in the literature. The compounds were tested for their ability to modulate hypoxia inducible factor-2 (HIF-2) transcription activity and all three showed HIF ...[more]