Ontology highlight
ABSTRACT:
SUBMITTER: Steller EJ
PROVIDER: S-EPMC3166455 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Steller Ernst J A EJ Ritsma Laila L Raats Danielle A E DA Hoogwater Frederik J H FJ Emmink Benjamin L BL Govaert Klaas M KM Laoukili Jamila J Rinkes Inne H M Borel IH van Rheenen Jacco J Kranenburg Onno O
EMBO reports 20110901 9
The death receptor CD95 promotes apoptosis through well-defined signalling pathways. In colorectal cancer cells, CD95 primarily stimulates migration and invasion through pathways that are incompletely understood. Here, we identify a new CD95-activated tyrosine kinase pathway that is essential for CD95-stimulated tumour cell invasion. We show that CD95 promotes Tyr 783 phosphorylation of phospholipase C-γ1 through the platelet-derived growth factor receptor-β, resulting in ligand-stimulated phosp ...[more]