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Functions of cofilin in cell locomotion and invasion.

ABSTRACT: Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

SUBMITTER: Bravo-Cordero JJ

PROVIDER: S-EPMC3878614 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Functions of cofilin in cell locomotion and invasion.

Bravo-Cordero Jose Javier JJ Magalhaes Marco A O MA Eddy Robert J RJ Hodgson Louis L Condeelis John J

Nature reviews. Molecular cell biology 20130619 7

Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin func ...[more]

PMID: 23778968

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