Ontology highlight
ABSTRACT:
SUBMITTER: Trujillo A
PROVIDER: S-EPMC3167188 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Trujillo Angelica A McGee Christie C Cogle Christopher R CR
Journal of oncology 20110905
Acute myeloid leukemia (AML) arises from neoplastic transformation of hematopoietic stem and progenitor cells, and relapsed disease remains one of the greater challenges in treating this hematologic malignancy. This paper focuses on angiogenic aspects of AML including the significance and prognostic value of bone marrow microvessel density and circulating cytokine levels. We show three general mechanisms whereby AML exploits angiogenic pathways, including direct induction of angiogenesis, paracr ...[more]