Ontology highlight
ABSTRACT:
SUBMITTER: Ou CY
PROVIDER: S-EPMC3168554 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Ou Chan-Yen CY Poon Vivian Y VY Maeder Celine I CI Watanabe Shigeki S Lehrman Emily K EK Fu Amy K Y AK Park Mikyoung M Fu Wing-Yu WY Jorgensen Erik M EM Ip Nancy Y NY Shen Kang K
Cell 20100501 5
Polarized trafficking of synaptic proteins to axons and dendrites is crucial to neuronal function. Through forward genetic analysis in C. elegans, we identified a cyclin (CYY-1) and a cyclin-dependent Pctaire kinase (PCT-1) necessary for targeting presynaptic components to the axon. Another cyclin-dependent kinase, CDK-5, and its activator p35, act in parallel to and partially redundantly with the CYY-1/PCT-1 pathway. Synaptic vesicles and active zone proteins mostly mislocalize to dendrites in ...[more]