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Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation.


ABSTRACT: Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile.

SUBMITTER: Wu J 

PROVIDER: S-EPMC3170163 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation.

Wu Jingjing J   Li Hui H   Cao Song S  

Beilstein journal of organic chemistry 20110808


Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel building block 2,2-difluoro-2-(phenylthio)acetic acid (2) as one component, followed by removal of the phenylsulfanyl protecting group in the presence of tributyltin hydride and azobisisobutyronitrile. ...[more]

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