Dataset Information

Androgen receptor CAG repeat size is associated with stress fracture risk: a pilot study.

ABSTRACT: BACKGROUND: Stress fractures commonly affect military recruits during basic training. Several lines of evidence suggest genetic factors are involved in stress fracture predisposition. As gender steroid hormone levels and activity have been implicated in affecting bone strength, one of the candidate genes likely to be involved is the androgen receptor gene. QUESTIONS/PURPOSES: We assessed the possible involvement of the androgen receptor gene in stress fracture predisposition in Israeli soldiers. PATIENTS AND METHODS: Between January 2007 and December 2009, we collected clinical and imaging data from 454 Israeli soldiers referred for bone scans with clinical symptoms compatible with stress fractures: 171 soldiers (154 men, 17 women) (patients) with bone scan-proven stress fractures and 283 soldiers (242 men, 41 women) with normal bone scans (control subjects). All participants were genotyped for the length of the CAG (cytosine-adenine-guanine) repeat in exon 1 of the androgen receptor gene using PCR and subsequent fragment analysis on sequence analyzer. RESULTS: The androgen receptor gene CAG repeat was ranged between six and 31 (mean ± SD, 20.6 ± 4.3) among patients and between 11 and 32 (mean ± SD, 20.0 ± 3.8) among control subjects. Smaller-sized (< 16) androgen receptor CAG repeats were more prevalent among control subjects (23%) than among patients (13%); the risk for having SFs was almost halved if the size of the repeat was shorter than 16 repeats. CONCLUSIONS: The androgen receptor gene CAG repeat has a different allele distribution among Israeli soldiers with stress fractures than in control subjects. While our finding must be validated, it could be used for screening individuals at risk for stress fractures. LEVEL OF EVIDENCE: Level II, prognostic study. See the Guidelines for Authors complete description of levels of evidence.

SUBMITTER: Yanovich R

PROVIDER: S-EPMC3171536 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Androgen receptor CAG repeat size is associated with stress fracture risk: a pilot study.

Yanovich Ran R Milgrom Roni R Friedman Eitan E Moran Daniel S DS

Clinical orthopaedics and related research 20110215 10

<h4>Background</h4>Stress fractures commonly affect military recruits during basic training. Several lines of evidence suggest genetic factors are involved in stress fracture predisposition. As gender steroid hormone levels and activity have been implicated in affecting bone strength, one of the candidate genes likely to be involved is the androgen receptor gene.<h4>Questions/purposes</h4>We assessed the possible involvement of the androgen receptor gene in stress fracture predisposition in Isra ...[more]

PMID: 21327417

Similar Datasets

Project description:There is a distinct increase in the prevalence of depression with the onset of puberty. The role of peripubertal testosterone levels in boys in this context is insufficiently understood and may be modulated by a functional polymorphism of the androgen receptor gene (AR), a variable number of CAG repeats. Moreover, there is preliminary evidence that the relationship between testosterone, CAG repeat length, and the severity of depressive symptoms may differ between subclinical and overt depression, but this has neither been studied in a clinical sample of adolescents with depression nor compared between subclinical and overt depression in an adequately powered study. To investigate the relationship between free testosterone, CAG repeat length of the AR, depression status (subclinical vs. overt), and the severity of depressive symptoms, 118 boys treated as in- or daycare patients at a single psychiatric hospital were studied. Of these, 73 boys had at least mild depressive symptoms according to the Beck Depression Inventory-II (BDI-II > 13). Higher-order moderation analysis in the multiple regression framework revealed a constant relationship between free testosterone and depression severity irrespective of the number of CAG repeats in adolescents with a BDI-II score ≤ 13. In adolescents with a BDI-II score > 13, however, there was a significant negative relationship between free testosterone and BDI-II score in patients with <19 CAG repeats and a significant positive relationship regarding free testosterone and BDI-II score in those with more than 28 CAG repeats, even when considering important covariates. These results suggest that the effects of testosterone on mood in male adolescents with depression depend on the genetic make-up of the AR as well as on depression status. This complex relationship should be considered by future studies addressing mental health issues against an endocrine background and may, moreover, contribute to tailored treatment concepts in psychiatric medicine, especially in adults.

Dataset Information

Androgen receptor CAG repeat size is associated with stress fracture risk: a pilot study.

Publications

Androgen receptor CAG repeat size is associated with stress fracture risk: a pilot study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets