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Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides.

ABSTRACT: A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides.

SUBMITTER: Wu Z

PROVIDER: S-EPMC3174090 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides.

Wu Zhimeng Z Guo Xueqing X Guo Zhongwu Z

Chemical communications (Cambridge, England) 20110708 32

A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides. ...[more]

PMID: 21738926

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