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Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis.

ABSTRACT: An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.

SUBMITTER: Li Z

PROVIDER: S-EPMC3582654 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis.

Li Zhou Z Chernyak Dmitri D Gevorgyan Vladimir V

Organic letters 20121128 23

An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields. ...[more]

PMID: 23190118

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