Ontology highlight
ABSTRACT:
SUBMITTER: Radosevic D
PROVIDER: S-EPMC6443897 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Radosevic Draginja D Sencanski Milan M Perovic Vladimir V Veljkovic Nevena N Prljic Jelena J Veljkovic Veljko V Mantlo Emily E Bukreyeva Natalya N Paessler Slobodan S Glisic Sanja S
Frontiers in cellular and infection microbiology 20190326
Influenza A virus (IAV) matrix protein 2 (M2), an ion channel, is crucial for virus infection, and therefore, an important anti-influenza drug target. Adamantanes, also known as M2 channel blockers, are one of the two classes of Food and Drug Administration-approved anti-influenza drugs, although their use was discontinued due to prevalent drug resistance. Fast emergence of resistance to current anti-influenza drugs have raised an urgent need for developing new anti-influenza drugs against resis ...[more]