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Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays.

ABSTRACT: A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research.

SUBMITTER: Praneenararat T 

PROVIDER: S-EPMC3175425 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Efficient synthesis and evaluation of quorum-sensing modulators using small molecule macroarrays.

Praneenararat Thanit T   Geske Grant D GD   Blackwell Helen E HE  

Organic letters 20091001 20

A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research. ...[more]

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