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A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone.

ABSTRACT: Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions.

SUBMITTER: Stark LM

PROVIDER: S-EPMC514435 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature

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A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone.

Stark Lucy M LM Pekari Klaus K Sorensen Erik J EJ

Proceedings of the National Academy of Sciences of the United States of America 20040701 33

Substantial structural transformations of much use in complex chemical synthesis can be achieved by channeling the reactivity of highly unsaturated molecules. This report describes the direct conversion of an acyclic polyunsaturated diketone to the HIV-1 Rev/Rev-responsive element inhibitor harziphilone under mild reaction conditions. ...[more]

PMID: 15232001

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