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Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.


ABSTRACT: BACKGROUND:We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, P(trend) = 0.003). METHODS:We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium. RESULTS:No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, P(trend) = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies. CONCLUSIONS:Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. IMPACT:Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations.

SUBMITTER: Amankwah EK 

PROVIDER: S-EPMC3176661 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature

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Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.

Amankwah Ernest K EK   Kelemen Linda E LE   Wang Qinggang Q   Song Honglin H   Chenevix-Trench Georgia G   Beesley Jonathan J   Webb Penelope M PM   Pearce Celeste L CL   Wu Anna H AH   Pike Malcolm C MC   Stram Daniel O DO   Chang-Claude Jenny J   Wang-Gohrke Shan S   Ness Roberta B RB   Goode Ellen L EL   Cunningham Julie M JM   Fridley Brooke L BL   Vierkant Robert A RA   Tworoger Shelley S SS   Whittemore Alice S AS   McGuire Valerie V   Sieh Weiva W   Gayther Simon A SA   Gentry-Maharaj Aleksandra A   Menon Usha U   Ramus Susan J SJ   Rossing Mary Anne MA   Doherty Jennifer A JA   Goodman Marc T MT   Carney Michael E ME   Lurie Galina G   Wilkens Lynne R LR   Kjær Susanne Krüger SK   Høgdall Estrid E   Cramer Daniel W DW   Terry Kathryn L KL   Garcia-Closas Montserrat M   Yang Hannah H   Lissowska Jolanta J   Anton-Culver Hoda H   Ziogas Argyrios A   Schildkraut Joellen M JM   Berchuck Andrew A   Pharoah Paul D P PD  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110317 5


<h4>Background</h4>We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, P(trend) = 0.003).<h4>Methods</h4>We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer  ...[more]

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