Ontology highlight
ABSTRACT:
SUBMITTER: Csordas G
PROVIDER: S-EPMC3178184 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Csordás György G Várnai Péter P Golenár Tünde T Roy Swati S Purkins George G Schneider Timothy G TG Balla Tamás T Hajnóczky György G
Molecular cell 20100701 1
The ER-mitochondrial junction provides a local calcium signaling domain that is critical for both matching energy production with demand and the control of apoptosis. Here, we visualize ER-mitochondrial contact sites and monitor the localized [Ca(2+)] changes ([Ca(2+)](ER-mt)) using drug-inducible fluorescent interorganelle linkers. We show that all mitochondria have contacts with the ER, but plasma membrane (PM)-mitochondrial contacts are less frequent because of interleaving ER stacks in both ...[more]