Ontology highlight
ABSTRACT:
SUBMITTER: Henne WM
PROVIDER: S-EPMC4539980 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Henne W Mike WM Zhu Lu L Balogi Zsolt Z Stefan Christopher C Pleiss Jeffrey A JA Emr Scott D SD
The Journal of cell biology 20150801 4
Although endolysosomal trafficking is well defined, how it is regulated and coordinates with cellular metabolism is unclear. To identify genes governing endolysosomal dynamics, we conducted a global fluorescence-based screen to reveal endomembrane effector genes. Screening implicated Phox (PX) domain-containing protein Mdm1 in endomembrane dynamics. Surprisingly, we demonstrate that Mdm1 is a novel interorganelle tethering protein that localizes to endoplasmic reticulum (ER)-vacuole/lysosome mem ...[more]