Emissive RNA alphabet.
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ABSTRACT:
SUBMITTER: Shin D
PROVIDER: S-EPMC3179766 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Emissive RNA alphabet.
Shin Dongwon D Sinkeldam Renatus W RW Tor Yitzhak Y
Journal of the American Chemical Society 20110902 38
A fluorescent ribonucleoside alphabet consisting of highly emissive purine ((th)A, (th)G) and pyrimidine ((th)U, (th)C) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses demonstrated that the emissive analogues are faithful isomorphic nucleoside surrogates. Photophysical analysis established that the nucleosides offer highly desirable qualities, including visible emission, high quantum yield, and responsiveness to e ...[more]
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