Unknown

Dataset Information

0

Genetics of bipolar disorder.


ABSTRACT: Bipolar disorder especially the most severe type (type I), has a strong genetic component. Family studies suggest that a small number of genes of modest effect are involved in this disorder. Family-based studies have identified a number of chromosomal regions linked to bipolar disorder, and progress is currently being made in identifying positional candidate genes within those regions. A number of candidate genes have also shown evidence of association with bipolar disorder, and genome-wide association studies are now under way, using dense genetic maps. Replication studies in larger or combined datasets are needed to definitively assign a role for specific genes in this disorder. This review covers our current knowledge of the genetics of bipolar disorder, and provides a commentary on current approaches used to identify the genes involved in this complex behavioral disorder.

SUBMITTER: Escamilla MA 

PROVIDER: S-EPMC3181866 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature

altmetric image

Publications

Genetics of bipolar disorder.

Escamilla Michael A MA   Zavala Juan M JM  

Dialogues in clinical neuroscience 20080101 2


Bipolar disorder especially the most severe type (type I), has a strong genetic component. Family studies suggest that a small number of genes of modest effect are involved in this disorder. Family-based studies have identified a number of chromosomal regions linked to bipolar disorder, and progress is currently being made in identifying positional candidate genes within those regions. A number of candidate genes have also shown evidence of association with bipolar disorder, and genome-wide asso  ...[more]

Similar Datasets

| S-EPMC3966627 | biostudies-literature
| S-EPMC3637882 | biostudies-literature
| S-EPMC7025814 | biostudies-literature
| S-EPMC5552237 | biostudies-literature
| S-EPMC6230336 | biostudies-literature
| S-EPMC5403662 | biostudies-literature
| PRJNA274435 | ENA
2019-11-12 | PXD009219 | Pride
| S-EPMC8044839 | biostudies-literature
| S-EPMC1180589 | biostudies-literature