Unknown

Dataset Information

0

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.


ABSTRACT: Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR <60ml/min/1.73m(2) at follow-up) and with ESRD in four case-control studies in subjects of European ancestry (3,775 cases, 4,577 controls). SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR) were associated with incident CKD; p-values ranged from p?=?4.1e-9 in UMOD to p?=?0.03 in GCKR. After adjusting for baseline eGFR, six of these loci remained significantly associated with incident CKD (UMOD, PRKAG2, ANXA9, DAB2, DACH1, and STC1). SNPs in UMOD (OR?=?0.92, p?=?0.04) and GCKR (OR?=?0.93, p?=?0.03) were nominally associated with ESRD. In summary, the majority of eGFR-related loci are either associated or show a strong trend towards association with incident CKD, but have modest associations with ESRD in individuals of European descent. Additional work is required to characterize the association of genetic determinants of CKD and ESRD at different stages of disease progression.

SUBMITTER: Boger CA 

PROVIDER: S-EPMC3183079 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

Böger Carsten A CA   Gorski Mathias M   Li Man M   Hoffmann Michael M MM   Huang Chunmei C   Yang Qiong Q   Teumer Alexander A   Krane Vera V   O'Seaghdha Conall M CM   Kutalik Zoltán Z   Wichmann H-Erich HE   Haak Thomas T   Boes Eva E   Coassin Stefan S   Coresh Josef J   Kollerits Barbara B   Haun Margot M   Paulweber Bernhard B   Köttgen Anna A   Li Guo G   Shlipak Michael G MG   Powe Neil N   Hwang Shih-Jen SJ   Dehghan Abbas A   Rivadeneira Fernando F   Uitterlinden André A   Hofman Albert A   Beckmann Jacques S JS   Krämer Bernhard K BK   Witteman Jacqueline J   Bochud Murielle M   Siscovick David D   Rettig Rainer R   Kronenberg Florian F   Wanner Christoph C   Thadhani Ravi I RI   Heid Iris M IM   Fox Caroline S CS   Kao W H WH  

PLoS genetics 20110929 9


Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed  ...[more]

Similar Datasets

| S-EPMC5383390 | biostudies-literature
| S-EPMC5042677 | biostudies-literature
| S-EPMC3013524 | biostudies-other
| S-EPMC5748906 | biostudies-literature
| S-EPMC5856088 | biostudies-literature
| S-EPMC6625615 | biostudies-literature
| S-EPMC3836481 | biostudies-literature
| S-EPMC4072910 | biostudies-literature
| S-EPMC5970998 | biostudies-literature
| S-EPMC4341483 | biostudies-literature