Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.
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ABSTRACT:
SUBMITTER: Seow WJ
PROVIDER: S-EPMC5856088 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.
Seow Wei Jie WJ Matsuo Keitaro K Hsiung Chao Agnes CA Shiraishi Kouya K Song Minsun M Kim Hee Nam HN Wong Maria Pik MP Hong Yun-Chul YC Hosgood H Dean HD Wang Zhaoming Z Chang I-Shou IS Wang Jiu-Cun JC Chatterjee Nilanjan N Tucker Margaret M Wei Hu H Mitsudomi Tetsuya T Zheng Wei W Kim Jin Hee JH Zhou Baosen B Caporaso Neil E NE Albanes Demetrius D Shin Min-Ho MH Chung Lap Ping LP An She-Juan SJ Wang Ping P Zheng Hong H Yatabe Yasushi Y Zhang Xu-Chao XC Kim Young Tae YT Shu Xiao-Ou XO Kim Young-Chul YC Bassig Bryan A BA Chang Jiang J Ho James Chung Man JC Ji Bu-Tian BT Kubo Michiaki M Daigo Yataro Y Ito Hidemi H Momozawa Yukihide Y Ashikawa Kyota K Kamatani Yoichiro Y Honda Takayuki T Sakamoto Hiromi H Kunitoh Hideo H Tsuta Koji K Watanabe Shun-Ichi SI Nokihara Hiroshi H Miyagi Yohei Y Nakayama Haruhiko H Matsumoto Shingo S Tsuboi Masahiro M Goto Koichi K Yin Zhihua Z Shi Jianxin J Takahashi Atsushi A Goto Akiteru A Minamiya Yoshihiro Y Shimizu Kimihiro K Tanaka Kazumi K Wu Tangchun T Wei Fusheng F Wong Jason Y Y JY Matsuda Fumihiko F Su Jian J Kim Yeul Hong YH Oh In-Jae IJ Song Fengju F Lee Victor Ho Fun VH Su Wu-Chou WC Chen Yuh-Min YM Chang Gee-Chen GC Chen Kuan-Yu KY Huang Ming-Shyan MS Yang Pan-Chyr PC Lin Hsien-Chih HC Xiang Yong-Bing YB Seow Adeline A Park Jae Yong JY Kweon Sun-Seog SS Chen Chien-Jen CJ Li Haixin H Gao Yu-Tang YT Wu Chen C Qian Biyun B Lu Daru D Liu Jianjun J Jeon Hyo-Sung HS Hsiao Chin-Fu CF Sung Jae Sook JS Tsai Ying-Huang YH Jung Yoo Jin YJ Guo Huan H Hu Zhibin Z Wang Wen-Chang WC Chung Charles C CC Lawrence Charles C Burdett Laurie L Yeager Meredith M Jacobs Kevin B KB Hutchinson Amy A Berndt Sonja I SI He Xingzhou X Wu Wei W Wang Junwen J Li Yuqing Y Choi Jin Eun JE Park Kyong Hwa KH Sung Sook Whan SW Liu Li L Kang Chang Hyun CH Hu Lingmin L Chen Chung-Hsing CH Yang Tsung-Ying TY Xu Jun J Guan Peng P Tan Wen W Wang Chih-Liang CL Sihoe Alan Dart Loon AD Chen Ying Y Choi Yi Young YY Hung Jen-Yu JY Kim Jun Suk JS Yoon Ho-Il HI Cai Qiuyin Q Lin Chien-Chung CC Park In Kyu IK Xu Ping P Dong Jing J Kim Christopher C He Qincheng Q Perng Reury-Perng RP Chen Chih-Yi CY Vermeulen Roel R Wu Junjie J Lim Wei-Yen WY Chen Kun-Chieh KC Chan John K C JK Chu Minjie M Li Yao-Jen YJ Li Jihua J Chen Hongyan H Yu Chong-Jen CJ Jin Li L Lo Yen-Li YL Chen Ying-Hsiang YH Fraumeni Joseph F JF Liu Jie J Yamaji Taiki T Yang Yang Y Hicks Belynda B Wyatt Kathleen K Li Shengchao A SA Dai Juncheng J Ma Hongxia H Jin Guangfu G Song Bao B Wang Zhehai Z Cheng Sensen S Li Xuelian X Ren Yangwu Y Cui Ping P Iwasaki Motoki M Shimazu Taichi T Tsugane Shoichiro S Zhu Junjie J Jiang Gening G Fei Ke K Wu Guoping G Chien Li-Hsin LH Chen Hui-Ling HL Su Yu-Chun YC Tsai Fang-Yu FY Chen Yi-Song YS Yu Jinming J Stevens Victoria L VL Laird-Offringa Ite A IA Marconett Crystal N CN Lin Dongxin D Chen Kexin K Wu Yi-Long YL Landi Maria Teresa MT Shen Hongbing H Rothman Nathaniel N Kohno Takashi T Chanock Stephen J SJ Lan Qing Q
Human molecular genetics 20170101 2
To evaluate associations by EGFR mutation status for lung adenocarcinoma risk among never-smoking Asian women, we conducted a meta-analysis of 11 loci previously identified in genome-wide association studies (GWAS). Genotyping in an additional 10,780 never-smoking cases and 10,938 never-smoking controls from Asia confirmed associations with eight known single nucleotide polymorphisms (SNPs). Two new signals were observed at genome-wide significance (P < 5 × 10-8), namely, rs7216064 (17q24.3, BPT ...[more]