Ontology highlight
ABSTRACT:
SUBMITTER: Miotto B
PROVIDER: S-EPMC3190045 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Miotto Benoit B Struhl Kevin K
Molecular cell 20111001 1
In response to environmental stresses, cells activate stress-response genes and inhibit DNA replication. HBO1 histone acetylase is a coactivator both for AP-1 transcription factors responding to stress-activated JNK kinases and also for the Cdt1 licensing factor that ensures that DNA is replicated exactly once per cell cycle. In response to nongenotoxic stress, JNK phosphorylates Jun, an AP-1 transcription factor, leading to increased recruitment of HBO1 and increased transcription of target gen ...[more]