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Rapid, general access to chiral beta-fluoroamines and beta,beta-difluoroamines via organocatalysis.

ABSTRACT: A rapid, general route to enantiopure beta-fluoroamines and beta,beta-difluoroamines has been developed employing organocatalysis in both a two-pot and a one-pot procedure. Both chemical yields (64-82%) and enantioselectivity (94-98% ee) were excellent and represent a significant improvement in the art of preparing chemically diverse beta-fluoroamines from readily available precursors.

SUBMITTER: Fadeyi OO

PROVIDER: S-EPMC3192010 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Rapid, general access to chiral beta-fluoroamines and beta,beta-difluoroamines via organocatalysis.

Fadeyi Olugbeminiyi O OO Lindsley Craig W CW

Organic letters 20090201 4

A rapid, general route to enantiopure beta-fluoroamines and beta,beta-difluoroamines has been developed employing organocatalysis in both a two-pot and a one-pot procedure. Both chemical yields (64-82%) and enantioselectivity (94-98% ee) were excellent and represent a significant improvement in the art of preparing chemically diverse beta-fluoroamines from readily available precursors. ...[more]

PMID: 19159275

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