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A general, enantioselective synthesis of ?- and ?-fluoroamines.

ABSTRACT: In this Letter, we describe a short, high yielding protocol for the enantioselective (87-96% ee) and general synthesis of ?-fluoroamines and previously difficult to access ?-fluoroamines from commercial aldehydes via organocatalysis.

SUBMITTER: O'Reilly MC

PROVIDER: S-EPMC3769685 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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A general, enantioselective synthesis of β- and γ-fluoroamines.

O'Reilly Matthew C MC Lindsley Craig W CW

Tetrahedron letters 20130701 28

In this Letter, we describe a short, high yielding protocol for the enantioselective (87-96% ee) and general synthesis of β-fluoroamines and previously difficult to access γ-fluoroamines from commercial aldehydes via organocatalysis. ...[more]

PMID: 24039308

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