EP4 receptor stimulation down-regulates human eosinophil function.
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ABSTRACT:
SUBMITTER: Luschnig-Schratl P
PROVIDER: S-EPMC3192285 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
EP4 receptor stimulation down-regulates human eosinophil function.
Luschnig-Schratl Petra P Sturm Eva M EM Konya Viktoria V Philipose Sonia S Marsche Gunther G Fröhlich Eleonore E Samberger Claudia C Lang-Loidolt Doris D Gattenlöhner Stefan S Lippe Irmgard Th IT Peskar Bernhard A BA Schuligoi Rufina R Heinemann Akos A
Cellular and molecular life sciences : CMLS 20110302 21
Accumulation of eosinophils in tissue is a hallmark of allergic inflammation. Here we observed that a selective agonist of the PGE(2) receptor EP4, ONO AE1-329, potently attenuated the chemotaxis of human peripheral blood eosinophils, upregulation of the adhesion molecule CD11b and the production of reactive oxygen species. These effects were accompanied by the inhibition of cytoskeletal rearrangement and Ca(2+) mobilization. The involvement of the EP4 receptor was substantiated by a selective E ...[more]
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