Ontology highlight
ABSTRACT:
SUBMITTER: Neves JS
PROVIDER: S-EPMC2587599 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Neves Josiane S JS Perez Sandra A C SA Spencer Lisa A LA Melo Rossana C N RC Reynolds Lauren L Ghiran Ionita I Mahmudi-Azer Salahaddin S Odemuyiwa Solomon O SO Dvorak Ann M AM Moqbel Redwan R Weller Peter F PF
Proceedings of the National Academy of Sciences of the United States of America 20081118 47
Intracellular granules in several types of leukocytes contain preformed proteins whose secretions contribute to immune and inflammatory functions of leukocytes, including eosinophils, cells notably associated with asthma, allergic inflammation, and helminthic infections. Cytokines and chemokines typically elicit extracellular secretion of granule proteins by engaging receptors expressed externally on the plasma membranes of cells, including eosinophils. Eosinophil granules, in addition to being ...[more]