Ontology highlight
ABSTRACT:
SUBMITTER: Chu SH
PROVIDER: S-EPMC3192304 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Chu Su Hee SH Roeder Kathryn K Ferrell Robert E RE Devlin Bernie B DeMichele-Sweet Mary Ann A MA Kamboh M Ilyas MI Lopez Oscar L OL Sweet Robert A RA
Neurobiology of aging 20110805 12
Apolipoprotein E (APOE) ε4 alleles increase the risk for late-onset Alzheimer disease (LOAD) and decrease the age of onset. Recently, sequencing the APOE region in a small sample of LOAD subjects identified a variable length poly-T repeat sequence in the nearby gene, TOMM40, which may affect age of onset. We genotyped the TOMM40 poly-T repeat using a novel statistical approach to refine the identification of allele length in 892 LOAD subjects and evaluated its effects on age of onset. Because ps ...[more]