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Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp.

ABSTRACT: Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 ?g/mL.

SUBMITTER: Prasad P

PROVIDER: S-EPMC3192506 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Papuamides E and F, Cytotoxic Depsipeptides from the Marine Sponge Melophlus sp.

Prasad Pritesh P Aalbersberg William W Feussner Klaus-D KD Van Wagoner Ryan M RM

Tetrahedron 20111101 44

Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 μg/mL. ...[more]

PMID: 22003260

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