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Cytotoxic sesterterpenoids from a sponge Hippospongia sp.

ABSTRACT: One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane-type sesterterpenes (3-8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported from this genus. Compounds 3-5 exhibited significant cytotoxicity against DLD-1, HCT-116, T-47D and K562 cancer cell lines.

SUBMITTER: Chang YC

PROVIDER: S-EPMC3397461 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Cytotoxic sesterterpenoids from a sponge Hippospongia sp.

Chang Yu-Chia YC Tseng Shang-Wei SW Liu Li-Lian LL Chou Yalan Y Ho Yuan-Shing YS Lu Mei-Chin MC Su Jui-Hsin JH

Marine drugs 20120427 5

One new pentacyclic sesterterpene, hippospongide A (1), and one new scalarane sesterterpenoid, hippospongide B (2), along with six previously reported known scalarane-type sesterterpenes (3-8), were isolated from a sponge Hippospongia sp. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. These metabolites are the first pentacyclic sesterterpene and scalarane-type sesterterpenes to be reported f ...[more]

PMID: 22822351

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