Ontology highlight
ABSTRACT:
SUBMITTER: Miller ST
PROVIDER: S-EPMC3193862 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Miller Scott T ST Rey Kathy K He Jin J Flanagan Jonathan J Fish Billie J BJ Rogers Zora R ZR Wang Winfred C WC Ware Russell E RE
Pediatric blood & cancer 20110708 1
The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) confirmed safety and efficacy of hydroxyurea therapy for infants with sickle cell anemia. Treatment was associated with reduction in rates of pain, acute chest syndrome, hospitalizations, and blood transfusions; improved hematologic values; and, perhaps, preservation of organ function. During the study, a 2-year-old ingested at one time an entire 35-day supply of hydroxyurea (612 mg/kg body weight). Despite a serum level of 7,756 µM 4 ...[more]