Ontology highlight
ABSTRACT:
SUBMITTER: Thornburg CD
PROVIDER: S-EPMC5600482 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Thornburg Courtney D CD Dixon Natalia N Burgett Shelly S Mortier Nicole A NA Schultz William H WH Zimmerman Sherri A SA Bonner Melanie M Hardy Kristina K KK Calatroni Agustin A Ware Russell E RE
Pediatric blood & cancer 20090501 5
<h4>Background</h4>Hydroxyurea improves laboratory parameters and prevents acute clinical complications of sickle cell anemia (SCA) in children and adults, but its effects on organ function remain incompletely defined.<h4>Methods</h4>To assess the safety and efficacy of hydroxyurea in young children with SCA and to prospectively assess kidney and brain function, 14 young children (mean age 35 months) received hydroxyurea at a mean maximum tolerated dose (MTD) of 28 mg/kg/day.<h4>Results</h4>Afte ...[more]