Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava A
PROVIDER: S-EPMC3196380 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Srivastava Aashish A Talaue Meliza M Liu Shuang S Degen David D Ebright Richard Y RY Sineva Elena E Chakraborty Anirban A Druzhinin Sergey Y SY Chatterjee Sujoy S Mukhopadhyay Jayanta J Ebright Yon W YW Zozula Alex A Shen Juan J Sengupta Sonali S Niedfeldt Rui Rong RR Xin Cai C Kaneko Takushi T Irschik Herbert H Jansen Rolf R Donadio Stefano S Connell Nancy N Ebright Richard H RH
Current opinion in microbiology 20110819 5
A new drug target - the 'switch region' - has been identified within bacterial RNA polymerase (RNAP), the enzyme that mediates bacterial RNA synthesis. The new target serves as the binding site for compounds that inhibit bacterial RNA synthesis and kill bacteria. Since the new target is present in most bacterial species, compounds that bind to the new target are active against a broad spectrum of bacterial species. Since the new target is different from targets of other antibacterial agents, com ...[more]