Ontology highlight
ABSTRACT:
SUBMITTER: Andrews WJ
PROVIDER: S-EPMC3576063 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Andrews William J WJ Panova Tatiana T Normand Christophe C Gadal Olivier O Tikhonova Irina G IG Panov Konstantin I KI
The Journal of biological chemistry 20130104 7
Transcription by RNA polymerase I (Pol-I) is the main driving force behind ribosome biogenesis, a fundamental cellular process that requires the coordinated transcription of all three nuclear polymerases. Increased Pol-I transcription and the concurrent increase in ribosome biogenesis has been linked to the high rates of proliferation in cancers. The ellipticine family contains a number of potent anticancer therapeutic agents, some having progressed to stage I and II clinical trials; however, th ...[more]